Detection of Tooth caries in Bitewing Radiographs using Deep Learning

Detection of Tooth caries in Bitewing Radiographs using Deep Learning

Muktabh Mayank Srivastava 
ParallelDots, Inc.
muktabh@paralleldots.com
\AndPratyush Kumar*
 ParallelDots, Inc.
pratyush@paralleldots.com
\ANDLalit Pradhan*
ParallelDots, Inc.
lalit@paralleldots.com
\AndSrikrishna Varadarajan
ParallelDots, Inc.
srikrishna@paralleldots.com
The authors contributed equallywww.paralleldots.xyz
Abstract

We develop a Computer Aided Diagnosis (CAD) system, which enhances the performance of dentists in detecting wide range of dental caries. The CAD System achieves this by acting as a second opinion for the dentists with way higher sensitivity on the task of detecting cavities than the dentists themselves. We develop annotated dataset of more than 3000 bitewing radiographs and utilize it for developing a system for automated diagnosis of dental caries. Our system consists of a deep fully convolutional neural network (FCNN) consisting 100+ layers, which is trained to mark caries on bitewing radiographs. We have compared the performance of our proposed system with three certified dentists for marking dental caries. We exceed the average performance of the dentists in both recall (sensitivity) and F1-Score (agreement with truth) by a very large margin. Working example of our system is shown in Figure 1.

 

Detection of Tooth caries in Bitewing Radiographs using Deep Learning


  Muktabh Mayank Srivastavathanks: The authors contributed equally ParallelDots, Inc.thanks: www.paralleldots.xyz muktabh@paralleldots.com Pratyush Kumar*  ParallelDots, Inc. pratyush@paralleldots.com Lalit Pradhan* ParallelDots, Inc. lalit@paralleldots.com Srikrishna Varadarajan ParallelDots, Inc. srikrishna@paralleldots.com

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noticebox[b]Workshop for ML in Health, 31st Conference on Neural Information Processing Systems (NIPS 2017), Long Beach, CA, USA.\end@float

Figure 1: Left: A representative bitewing radiograph. Right: Bounding box in red color representing caries predicted by our system

1 Introduction

Dental caries (also known as Dental Cavities) are major oral health problem in most industrialized countries, affecting more than one-fourth of U.S. children aged two to five, half of those aged between twelve to fifteen, and more than 90 percent of U.S. adults over age 40 Graef []. Consequently, dental services (including diagnosis, prevention, and treatment of the diseases related to oral cavity) are among the fastest growing sectors in the healthcare industry medGadget []. Dentists often use bitewing radiographs as assisting tools to locate dental caries. This, however, is a challenging task. Dentists rely on clinical experience and patient’s medical history as additional information for corroborating their caries findings on radiographs. Even experienced dentists miss cavities with high probability (20%-40%) Solmaz and Mostafa [], if presented with just the bitewing radiographs. Further, intra- as well as inter-examiner agreement between dentists are very low Valachovic and Douglass []. Automating the dental caries detection process has huge potential in raising standards of medical care by providing increased efficiency and reliability. Our contributions in the present work are as follows:

  • We develop a large annotated dataset from clinically verified bitewing radiographs

  • We develop a system for automated detection of dental caries from bitewing radiographs

  • We benchmark the efficiency of our proposed system with three practising dentists

We develop a System that has better agreement (F1-Score) with clinically verified data as compared to 3 dentists we work with during our study. On top of this the sensitivity of the system is higher than dentists as well. The study was approved by IRB.

2 Related Work

Machine learning is a discipline within computer science that focuses on teaching machines to detect patterns in the underlying data Bishop [2006]. Machine learning techniques have been previously leveraged for a variety of object detection tasks in natural images. For the task of dental caries detection, very less research work exists that uses traditional machine learning methods. Such traditional machine learning methods are limited by their limited modelling capacities, reliance on feature engineering, and ability to work under specialized non-clinical environments (e.g. detection in extracted tooth artificially arranged for the process). The proposed system, however, is an end-to-end solution, which detects dental cavities directly from the original radiographs without needing any specialized tailoring of images. This has been possible by using methods of Deep learning, specifically a type of Convolutional Neural Networks Stanford [] called fully convolutional Neural Networks Ronneberger et al. [].

3 Methods

3.1 Data Set

We obtained over 3000 bitewing radiographs from approximately 100 clinics across USA after approval from IRB. All the radiographs were annotated by certified dentists after clinical verification for existence of dental caries. These annotations were used as ground truth for both training as well as testing. We used 2500 radiographs for training our system. The remaining 500 radiographs were used for testing. These 500 radiographs used for testing were given for marking caries to three practising dentists (henceforth, referred to as testing dentists), who were unaware of the clinical history of the patient. The marking of the testing dentists and our system were compared against the ground truth.

3.2 Development of the System

The caries detection task is a dense classification task which takes as input a bitewing radiograph 2-d image and outputs a binary labels (0 or 1) for each pixel. Each output label corresponds to a pixel of the input being caries or not. We develop a 100+ layers deep neural network to learn the dense classification task for dental cavities in the bitewing radiographs. Deep learning is the process of training a neural network (a large mathematical function with millions of parameters) to perform a given task.

3.3 Testing the System

Dental cavities appear in amoeboid shapes in the bitewing radiographs, which is quite difficult to annotate. Therefore, we obtained the annotations as bounding box around the caries. The prediction of our system were also converted to bounding boxes. We use Jaccard index Wiki [] (also known as Intersection over Union, IoU) to compare the similarity between the predictions from both our System and testing dentists with the ground truths. We consider Jaccard index of 0.8 or above as a match between predictions and ground truth. We report the results using Recall (Sensitivity) , Precision (positive predictive value) and Agreement with truth (F1-score).

4 Experiments and Result

The precision, recall and F1-score of our system along with the testing dentists is tabulated in Table 1. The results clearly demonstrate that our system outperforms the dentists in both sensitivity in predicting caries as well as F1-score by a large margin.

System Dr. 1 Dr. 2 Dr. 3
Recall 80.5 47.7 43 34.4
Precision 61.5 63 81.5 89.1
F1-Score 70 54 56 50
Table 1: Performance comparison between our system and testing dentists

5 Conclusion

The use of Computer Aided Diagnosis (CAD) System for clinical diagnosis provides improved performance and reliability along with avoiding problems caused by intra- and inter- examiner variations. We have presented a System, which automatically finds dental caries in bitewing radiographs. We benchmark the performance of our system againsts three practicing dentists. Based on the results, we can conclude that our System achieves optimal performance on finding dental caries in bitewing radiographs.

References

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